# Problems after upgrading Ubuntu to 22 **URL:** \ **Category:** Uncategorized\ **Tags:** galaxy-local\ **Created:** [August 29, 2022, 5:14am UTC](https://help.galaxyproject.org/t/problems-after-upgrading-ubuntu-to-22/8544 "2022-08-29T05:14:58Z")\ **Posts on this page:** 7\ **Page:** 1
**Author:** ![cass](https://avatars.discourse-cdn.com/v4/letter/c/ecccb3/32.png) [@cass](https://help.galaxyproject.org/u/cass)\ **Post date:** [August 29, 2022, 5:14am UTC](https://help.galaxyproject.org/t/problems-after-upgrading-ubuntu-to-22/8544/1 "2022-08-29T05:14:58Z")
Hi everyone, I just upgraded my Ubuntu 20 to 22, which obviously included an upgrade from python 3.9 to 3.10. However, when I try to start Galaxy using the run.sh script, I now receive the following error: * * * Activating virtualenv at .venv Could not find platform independent libraries Could not find platform dependent libraries \ Consider setting $PYTHONHOME to [:\] Python path configuration: PYTHONHOME = (not set) PYTHONPATH = (not set) program name = ‘python’ isolated = 0 environment = 1 user site = 1 import site = 1 sys.\_base\_executable = ‘/home/michael/Galaxy/galaxy/.venv/bin/python’ sys.base\_prefix = ‘/usr’ sys.base\_exec\_prefix = ‘/usr’ sys.platlibdir = ‘lib’ sys.executable = ‘/home/michael/Galaxy/galaxy/.venv/bin/python’ sys.prefix = ‘/usr’ sys.exec\_prefix = ‘/usr’ sys.path = [ ‘/usr/lib/python39.zip’, ‘/usr/lib/python3.9’, ‘/usr/lib/lib-dynload’, ] Fatal Python error: init\_fs\_encoding: failed to get the Python codec of the filesystem encoding Python runtime state: core initialized ModuleNotFoundError: No module named ‘encodings’ ## Current thread 0x00007f09efe2a000 (most recent call first): Can anyone help me how to fix that? Best Peter ---
**Author:** ![gallardoalba](https://sea2.discourse-cdn.com/flex020/user_avatar/help.galaxyproject.org/gallardoalba/32/1903_2.png) [@gallardoalba](https://help.galaxyproject.org/u/gallardoalba)\ **Post date:** [August 29, 2022, 12:07pm UTC](https://help.galaxyproject.org/t/problems-after-upgrading-ubuntu-to-22/8544/2 "2022-08-29T12:07:14Z")
> [@cass](#): > > Fatal Python error: init\_fs\_encoding: failed to get the Python codec of the filesystem encoding Hi @cass, could you try to remove the PYTHONPATH and PYTHONHOME variables? ```auto unset PYTHONPATH unset PYTHONHOME ``` Regards ---
**Author:** ![cass](https://avatars.discourse-cdn.com/v4/letter/c/ecccb3/32.png) [@cass](https://help.galaxyproject.org/u/cass)\ **Post date:** [August 29, 2022, 9:34pm UTC](https://help.galaxyproject.org/t/problems-after-upgrading-ubuntu-to-22/8544/3 "2022-08-29T21:34:04Z")
Thanks for the input! However, this does not change the error. I have tried to install python 3.9, but it just gives me errors anyway… ---
**Author:** ![FelixSchmidmeir](https://sea2.discourse-cdn.com/flex020/user_avatar/help.galaxyproject.org/felixschmidmeir/32/3821_2.png) [@FelixSchmidmeir](https://help.galaxyproject.org/u/FelixSchmidmeir)\ **Post date:** [November 14, 2022, 9:46pm UTC](https://help.galaxyproject.org/t/problems-after-upgrading-ubuntu-to-22/8544/4 "2022-11-14T21:46:47Z")
Did you find a solution for this issue? I am having exactly the same problem ---
**Author:** ![jennaj](https://sea2.discourse-cdn.com/flex020/user_avatar/help.galaxyproject.org/jennaj/32/27_2.png) [@jennaj](https://help.galaxyproject.org/u/jennaj)\ **Post date:** [November 16, 2022, 10:40pm UTC](https://help.galaxyproject.org/t/problems-after-upgrading-ubuntu-to-22/8544/5 "2022-11-16T22:40:00Z")
Hi @FelixSchmidmeir I’ve cross-posted your question over to the admin’s chat. They may reply here or there, and feel free to join the chat. Minimally, sharing the version of Galaxy you are running would be helpful. `22.05` is the most current stable release and is recommended for everyone. [releases/index](https://docs.galaxyproject.org/en/master/releases/index.html). Matrix [You're invited to talk on Matrix](https://matrix.to/#/!rfLDbcWEWZapZrujix:gitter.im/%24iHbxvKLt9lVJ4OpF3Di5P-beqxmrUmhEdG_2Q96Nm-w?via=gitter.im&via=matrix.org) Gitter [galaxyproject/admins - Gitter](https://gitter.im/galaxyproject/admins?at=637565e20513b562e8b3740e) ---
**Author:** ![nsoranzo](https://sea2.discourse-cdn.com/flex020/user_avatar/help.galaxyproject.org/nsoranzo/32/77_2.png) [@nsoranzo](https://help.galaxyproject.org/u/nsoranzo)\ **Post date:** [November 16, 2022, 10:59pm UTC](https://help.galaxyproject.org/t/problems-after-upgrading-ubuntu-to-22/8544/6 "2022-11-16T22:59:26Z")
Can you try by following the instructions in [Supported Python versions — Galaxy Project 22.05.1 documentation](https://docs.galaxyproject.org/en/master/admin/python.html) ? In particular, start by removing the existing virtual environment (by default the `.venv` subdirectory). ---
**Author:** ![jennaj](https://sea2.discourse-cdn.com/flex020/user_avatar/help.galaxyproject.org/jennaj/32/27_2.png) [@jennaj](https://help.galaxyproject.org/u/jennaj)\ **Post date:** [May 8, 2026, 1:59am UTC](https://help.galaxyproject.org/t/problems-after-upgrading-ubuntu-to-22/8544/7 "2026-05-08T01:59:40Z")