# Should i change de EntrezID of my genes if it has changed in NCBI?

**URL:** <https://help.galaxyproject.org/t/should-i-change-de-entrezid-of-my-genes-if-it-has-changed-in-ncbi/6681>\
**Category:** usegalaxy.org support\
**Tags:** annotatemyids, reference-annotation\
**Created:** [September 15, 2021, 8:34pm UTC](https://help.galaxyproject.org/t/should-i-change-de-entrezid-of-my-genes-if-it-has-changed-in-ncbi/6681 "2021-09-15T20:34:22Z")\
**Posts on this page:** 4\
**Page:** 1

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**Author:** ![CamiOsega](https://avatars.discourse-cdn.com/v4/letter/c/6a8cbe/32.png) [@CamiOsega](https://help.galaxyproject.org/u/CamiOsega)\
**Post date:** [September 15, 2021, 8:34pm UTC](https://help.galaxyproject.org/t/should-i-change-de-entrezid-of-my-genes-if-it-has-changed-in-ncbi/6681/1 "2021-09-15T20:34:22Z")

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I was using the “Annotated my IDs - FeatureCounts” tool when i realize that some of my genes had a NA tag, so i went to the NCBI page to check and it said “This record was replaced with Gene ID: XXXX”. Can i just replace them? or should i check somehow if this new gene correspond to my previous annotated ones?

Thxs

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**Author:** ![jennaj](https://sea2.discourse-cdn.com/flex020/user_avatar/help.galaxyproject.org/jennaj/32/27_2.png) [@jennaj](https://help.galaxyproject.org/u/jennaj)\
**Post date:** [September 16, 2021, 1:36am UTC](https://help.galaxyproject.org/t/should-i-change-de-entrezid-of-my-genes-if-it-has-changed-in-ncbi/6681/2 "2021-09-16T01:36:18Z")

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Hi @CamiOsega

The annotation was based on the original record. Checking to see what changed would be a very good idea. It would be your decision about whether or not any specific changes could impact the larger results in a way significant for your analysis purposes (if any, besides the name label).

New or different transcripts associated with that record would probably be considered a significant change since that could make the result non-reproducible, even if just in a small way.

Hope that helps

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**Author:** ![CamiOsega](https://avatars.discourse-cdn.com/v4/letter/c/6a8cbe/32.png) [@CamiOsega](https://help.galaxyproject.org/u/CamiOsega)\
**Post date:** [September 16, 2021, 1:37pm UTC](https://help.galaxyproject.org/t/should-i-change-de-entrezid-of-my-genes-if-it-has-changed-in-ncbi/6681/3 "2021-09-16T13:37:01Z")

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Thank you so much Jennnaj. I will review the data!  
Sincerely Camila

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**Author:** ![jennaj](https://sea2.discourse-cdn.com/flex020/user_avatar/help.galaxyproject.org/jennaj/32/27_2.png) [@jennaj](https://help.galaxyproject.org/u/jennaj)\
**Post date:** [April 8, 2026, 1:14am UTC](https://help.galaxyproject.org/t/should-i-change-de-entrezid-of-my-genes-if-it-has-changed-in-ncbi/6681/4 "2026-04-08T01:14:53Z")

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