# variant's prediction of pathogenicity

**URL:** <https://help.galaxyproject.org/t/variants-prediction-of-pathogenicity/13464>\
**Category:** usegalaxy.org support\
**Tags:** gtn-tutorial, variant-analysis\
**Created:** [September 16, 2024, 2:14pm UTC](https://help.galaxyproject.org/t/variants-prediction-of-pathogenicity/13464 "2024-09-16T14:14:24Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![Lucia1](https://avatars.discourse-cdn.com/v4/letter/l/eada6e/32.png) [@Lucia1](https://help.galaxyproject.org/u/Lucia1)\
**Post date:** [September 16, 2024, 2:14pm UTC](https://help.galaxyproject.org/t/variants-prediction-of-pathogenicity/13464/1 "2024-09-16T14:14:24Z")

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HI ! I’m wondering if there is an option to run pathogenicity prediction of genetic variants using the ACMG parameters. Thank you so much!

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**Author:** ![jennaj](https://sea2.discourse-cdn.com/flex020/user_avatar/help.galaxyproject.org/jennaj/32/27_2.png) [@jennaj](https://help.galaxyproject.org/u/jennaj)\
**Post date:** [September 17, 2024, 4:26pm UTC](https://help.galaxyproject.org/t/variants-prediction-of-pathogenicity/13464/2 "2024-09-17T16:26:46Z")

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HI @Lucia1

For variant calling and annotation, please start with the tutorials here

> **[Variant Analysis / Tutorial List](https://training.galaxyproject.org/training-material/topics/variant-analysis/)**
>
> Genetic differences (variants) between healthy and diseased tissue, between individuals of a population, or between strains of an organism can provide mechanistic insight into disease processes and the natural function of affected genes. The...

then see the variant sections in other groups like this one.

> **[One Health / Tutorial List](https://training.galaxyproject.org/training-material/topics/one-health/)**
>
> One Health is unified approach that aims to sustainably balance the health of humans, animals, and ecosystems, as all of the health of each of these groups is closely interlinked.

If you want to share more details – maybe a publication or other protocol that you are trying to replicate? – we can try to help more.

Let’s start there. 🙂