Welcome, @Imran_Noorani
We have a really comprehensive post about using the gnomAD reference data at a UseGalaxy server. Try at UseGalaxy.eu since they can handle data of this size best.
If you are not sure how to work with VCF data, please see our tutorials here for some examples, guides, and workflow templates!
- Tutorials, main topic → Variant Analysis / Tutorial List
- Query for all by keyword → GTN Materials Search (query=variant)
Hope this helps! 