hi @maryam-gh99 we probably might have discussed about it but I am still replying here so that other users might benefit.
The default normalizations by Scanpy and Scran are different. Scanpy uses a simple shifted logarithm whereas scran estimates size factors by pooling cells. Please refer to the single-cell best practices guide to learn some basic details about those two normalization methods. There is always a debate that the choice of normalization method should be based on the post-processing steps. However, this recent benchmark of scRNA-seq normalization methods showed that shifted logarithm performed quite well. We have both the Scran and Scanpy normalizations available on Galaxy.