Update: Did fine one problem with the default Conda venv method (and there could be others!) – loading a fasa dataset into an IGV local browser fails, for some dependency (possibly Samtools but that is just a guess!).
Discovered during this Q&A: Local IGV with Galaxy doesn't work
Even people with administrative experience will start over and use the Python venv rather than attempt to fix the various issues that can come up when using a Conda venv.
So – it is definitely recommended to use a Python venv to avoid unnecessary issues.