Hi. I occasionally run a local version of Galaxy using Terminal on my MacBook Pro. Would this be expected to contribute to the System Data on my Mac? (trying to trace the source of a large amount of System Data I need to clean up). Thanks
Welcome, @HMcBain
Try visiting a MacOS forum for advice about how to untangled application data from other important files on your computer. Review the breakdown of what applications are contributing data into your storage partitions. Galaxy is just like any other application you may have installed and are running so there isn’t anything special to consider as far as I know.
Hopefully this helps! 
I’m also not an OSX user and can help with detailed information. If you can use the Terminal, try using du -h /path/to/Galaxy/ and see what the output is. Galaxy need to store the data that it is processing, depending on what you are doing it can take large amounts of storage, usually under the ./database directory.
Hope that helps,
Bjoern
Galaxy will store everything that you use, so if you load or produce large (or many smaller) datasets then Galaxy will store them (even if you copy it out, or delete the original outside of Galaxy). This will contribute to the size od the data on the system.
You should maintain datasets in your Galaxy similarly as you maintain datasets on your disk. In configuration of your galaxy enable purging of datasets and then delete the datasets you do not want to use. Check out this training for more details and ideas: FAQ: How can I reduce quota usage while still retaining prior work (data, tools, methods)?
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